| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Serine incorporator 5 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SERINC5 |
| Gene ID: |
256987 |
| Uniprot ID: |
SERC5_HUMAN |
| Specificity: |
This antibody detects endogenous levels of SERINC5 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human SERINC5 |
| Function | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes. |
| Protein Name | Serine Incorporator 5 |
| Database Links | Reactome: R-HSA-977347 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear Region(Microbial Infection) Upon Hiv-1 InfectionIt Is Redirected To Perinuclear Region Following Interaction With Hiv-1 NefExcluding It From Virions ParticlesThereby Preventing Subsequent Antiviral Defense ActivityLocalizes To The Cell MembraneWhere It Is Efficiently Incorporated Into Budding Virions And Impairs Subsequent Virion Entry Into Target Cells |
| Alternative Antibody Names | Anti-Serine Incorporator 5 antibodyAnti-SERINC5 antibodyAnti-C5orf12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
