Anti-SERINC5 antibody (STJA0008214)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SERINC5
General Information
| Short Description | Rabbit polyclonal anti-Serine incorporator 5 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SERINC5 |
| Gene ID | 256987 |
| Uniprot ID | SERC5_HUMAN |
| Immunogen | Synthesized peptide derived from human SERINC5 |
| Specificity | This antibody detects endogenous levels of SERINC5 at Human, Mouse, Rat |
Additional Info
| Function | Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in HIV-1 surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to changes in HIV-1 Env conformation and loss of infectivity. Enhances the incorporation of serine into phosphatidylserine and sphingolipids. May play a role in providing serine molecules for the formation of myelin glycosphingolipids in oligodendrocytes. |
| Protein Name | Serine Incorporator 5 |
| Database Links | Reactome: R-HSA-977347 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmPerinuclear Region(Microbial Infection) Upon Hiv-1 InfectionIt Is Redirected To Perinuclear Region Following Interaction With Hiv-1 NefExcluding It From Virions ParticlesThereby Preventing Subsequent Antiviral Defense ActivityLocalizes To The Cell MembraneWhere It Is Efficiently Incorporated Into Budding Virions And Impairs Subsequent Virion Entry Into Target Cells |
| Alternative Antibody Names | Anti-Serine Incorporator 5 antibodyAnti-SERINC5 antibodyAnti-C5orf12 antibody |
Information sourced from Uniprot.org