Anti-Semaphorin-6A antibody (C-Term) (STJA0041409)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSemaphorin 6A synthetic peptide (coupled to carrier protein) corresponding to amino acids in the C-terminus of human Sema-6A. The sequence used is identical to similar regions in rat and mouse Sema-6A, and has low homology to other semaphorin family
General Information
| Short Description | Rabbit polyclonal anti-Semaphorin-6A (C-Term) for use in ELISA, WB, ICC and IP in Chicken, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IP |
| Host | Rabbit |
| Reactivity | Chicken/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:500ICC 1:100IP 1:100 |
| Formulation | PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol |
| Storage Instruction | Storage at-20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at-20°C. |
Target Information
| Gene Symbol | SEMA6A |
| Gene ID | 57556 |
| Uniprot ID | SEM6A_HUMAN |
| Immunogen | Semaphorin 6A synthetic peptide (coupled to carrier protein) corresponding to amino acids in the C-terminus of human Sema-6A. The sequence used is identical to similar regions in rat and mouse Sema-6A, and has low homology to other semaphorin family |
| Immunogen Region | C-Term |
| Immunogen Sequence | Human |
| Specificity | The antibody detects a 120kDa* protein corresponding to the apparent molecular mass of Sema-6A on SDS-PAGE immunoblots of Sema-6A transfected COS7 cells, human colorectal cancer cells, and rat PC12 cells. In addition, shRNA knockdown of Sema-6A expre |
Additional Info
| Function | Cell surface receptor for PLXNA2 that plays an important role in cell-cell signaling. Required for normal granule cell migration in the developing cerebellum. Promotes reorganization of the actin cytoskeleton and plays an important role in axon guidance in the developing central nervous system. Can act as repulsive axon guidance cue. Has repulsive action towards migrating granular neurons. May play a role in channeling sympathetic axons into the sympathetic chains and controlling the temporal sequence of sympathetic target innervation. (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium. |
| Protein Name | Semaphorin-6aSemaphorin ViaSema ViaSemaphorin-6a-1Sema6a-1 |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Semaphorin-6a antibodyAnti-Semaphorin Via antibodyAnti-Sema Via antibodyAnti-Semaphorin-6a-1 antibodyAnti-Sema6a-1 antibodyAnti-SEMA6A antibodyAnti-KIAA1368 antibodyAnti-SEMAQ antibody |
Information sourced from Uniprot.org