| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SEMA4A |
| Gene ID: | 64218 |
| Uniprot ID: | SEM4A_HUMAN |
| Immunogen Region: | 320-580 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-580 of human SEMA4A (NP_071762.2). |
| Immunogen Sequence: | IYAVFTSQWQVGGTRSSAVC AFSLLDIERVFKGKYKELNK ETSRWTTYRGPETNPRPGSC SVGPSSDKALTFMKDHFLMD EQVVGTPLLVKSGVEYTRLA VETAQGLDGHSHLVMYLGTT TGSLHKAVVSGDSSAHLVEE IQLFPDPEPVRNLQLAPTQG AVFVGFSGGVWRVPRANCSV YESCVDCVLARDPHCAWDPE SRTCCLLSAPNLNSWKQDME RGNPEWACASGPMSRSLRP |
| Function | Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. |
| Protein Name | Semaphorin-4aSemaphorin-BSema B |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Semaphorin-4a antibodyAnti-Semaphorin-B antibodyAnti-Sema B antibodyAnti-SEMA4A antibodyAnti-SEMAB antibodyAnti-SEMB antibodyAnti-UNQ783 antibodyAnti-PRO1317 antibody |
Information sourced from Uniprot.org