| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SEL1L |
| Gene ID: |
6400 |
| Uniprot ID: |
SE1L1_HUMAN |
| Immunogen Region: |
22-190 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 22-190 of human SEL1L (NP_005056.3). |
| Immunogen Sequence: |
SSDEEGSQDESLDSKTTLTS DESVKDHTTAGRVVAGQIFL DSEESELESSIQEEEDSLKS QEGESVTEDISFLESPNPEN KDYEEPKKVRKPALTAIEGT AHGEPCHFPFLFLDKEYDEC TSDGREDGRLWCATTYDYKA DEKWGFCETEEEAAKRRQMQ EAEMMYQTG |
| Tissue Specificity | Highly expressed in pancreas. |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. |
| Protein Name | Protein Sel-1 Homolog 1Suppressor Of Lin-12-Like Protein 1Sel-1l |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-382556Reactome: R-HSA-5358346Reactome: R-HSA-5362768Reactome: R-HSA-5678895Reactome: R-HSA-901032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Protein Sel-1 Homolog 1 antibodyAnti-Suppressor Of Lin-12-Like Protein 1 antibodyAnti-Sel-1l antibodyAnti-SEL1L antibodyAnti-TSA305 antibodyAnti-UNQ128 antibodyAnti-PRO1063 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
