Immunohistochemistry analysis of SEC14L2 in paraffin-embedded human liver tissue using SEC14L2 Rabbit polyclonal antibody (STJ11105363) at a dilution of 1:100 (40x lens). High pressure antigen retrieval was performed with 0. 01 M citrate buffer (pH 6. 0) prior to immunohistochemistry staining.

Anti-SEC14L2 antibody (1-275) (STJ11105363)

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STJ11105363
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Host: Rabbit
Applications: IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SEC14L2
Gene ID: 23541
Uniprot ID: S14L2_HUMAN
Immunogen Region: 1-275
Specificity: Recombinant Protein corresponding to a sequence within amino acids 1-275 of human SEC14L2 (NP_203740.1).
Immunogen Sequence: MSGRVGDLSPRQKEALAKFR ENVQDVLPALPNPDDYFLLR WLRARSFDLQKSEAMLRKHV EFRKQKDIDNIISWQPPEVI QQYLSGGMCGYDLDGCPVWY DIIGPLDAKGLLFSASKQDL LRTKMRECELLLQECAHQTT KLGRKVETITIIYDCEGLGL KHLWKPAVEAYGEFLCMFEE NYPETLKRLFVVKAPKLFPV AYNLIKPFLSEDTRKKIMVL GANWKEVLLKHISPDQVPV
Tissue Specificity Widely expressed. Strong expression in liver, brain and prostate.
Function Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Protein Name Sec14-Like Protein 2
Alpha-Tocopherol-Associated Protein
Tap
Htap
Squalene Transfer Protein
Supernatant Protein Factor
Spf
Cellular Localisation Cytoplasm
Nucleus
Cytoplasmic In Absence Of Alpha-Tocopherol
And Nuclear In Presence Of Alpha-Tocopherol
Alternative Antibody Names Anti-Sec14-Like Protein 2 antibody
Anti-Alpha-Tocopherol-Associated Protein antibody
Anti-Tap antibody
Anti-Htap antibody
Anti-Squalene Transfer Protein antibody
Anti-Supernatant Protein Factor antibody
Anti-Spf antibody
Anti-SEC14L2 antibody
Anti-C22orf6 antibody
Anti-KIAA1186 antibody
Anti-KIAA1658 antibody

Information sourced from Uniprot.org

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