| Short Description : | Rabbit polyclonal SEC14L2 (60-270) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SEC14L2 |
| Gene ID: | 23541 |
| Uniprot ID: | S14L2_HUMAN |
| Immunogen Region: | 60-270 |
| Immunogen Sequence: | GRKVETITIIYDCEGLGLKH LWKPAVEAYGEFLCMFEENY PETLKRLFVVKAPKLFPVAY NLIKPFLSEDTRKKIMVLGA NWKEVLLKHISPDQVPVEYG GTMTDPDGNPKCKSKINYGG DIPRKYYVRDQVKQQYEHSV QISRGSSHQVEYEILFPGCV LRWQFMSDGADVGFGIFLKT KMGERQRAGEMTEVLPNQRY NSHLVPEDGTL |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-270 of human SEC14L2 (NP_001191133.1). |
| Tissue Specificity | Widely expressed. Strong expression in liver, brain and prostate. |
| Function | Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. |
| Protein Name | Sec14-Like Protein 2Alpha-Tocopherol-Associated ProteinTapHtapSqualene Transfer ProteinSupernatant Protein FactorSpf |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusCytoplasmic In Absence Of Alpha-TocopherolAnd Nuclear In Presence Of Alpha-Tocopherol |
| Alternative Antibody Names | Anti-Sec14-Like Protein 2 antibodyAnti-Alpha-Tocopherol-Associated Protein antibodyAnti-Tap antibodyAnti-Htap antibodyAnti-Squalene Transfer Protein antibodyAnti-Supernatant Protein Factor antibodyAnti-Spf antibodyAnti-SEC14L2 antibodyAnti-C22orf6 antibodyAnti-KIAA1186 antibodyAnti-KIAA1658 antibody |
Information sourced from Uniprot.org
