Formalin-fixed, paraffin-embedded succinate dehydrogenase deficient RCC stained with anti-SDHB antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of tumor cells

Anti-SDHB antibody [ZR339] (STJ180540)

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STJ180540
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Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-SDHB is suitable for use in Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : ZR339
Conjugation: Unconjugated
Isotype: Rabbit IgG
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:100-200
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: SDHB
Gene ID: 6390
Uniprot ID: SDHB_HUMAN
Specificity: Positive control: GIST
Immunogen: Synthetic peptide corresponding to residues in human SDHB was used as an immunogen
Function Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate.
Protein Name Succinate Dehydrogenase Ubiquinone Iron-Sulfur Subunit - Mitochondrial
Iron-Sulfur Subunit Of Complex Ii
Ip
Malate Dehydrogenase Quinone Iron-Sulfur Subunit
Database Links Reactome: R-HSA-611105
Reactome: R-HSA-71403
Reactome: R-HSA-9854311
Cellular Localisation Mitochondrion Inner Membrane
Peripheral Membrane Protein
Matrix Side
Alternative Antibody Names Anti-Succinate Dehydrogenase Ubiquinone Iron-Sulfur Subunit - Mitochondrial antibody
Anti-Iron-Sulfur Subunit Of Complex Ii antibody
Anti-Ip antibody
Anti-Malate Dehydrogenase Quinone Iron-Sulfur Subunit antibody
Anti-SDHB antibody
Anti-SDH antibody
Anti-SDH1 antibody

Information sourced from Uniprot.org

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