Anti-SDCCAG8 antibody (Internal) (STJ72779)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SDCCAG8 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 80kDa band observed in lysates of cell line HEK293 (calculated MW of 82.7kDa according to NP_006633.1). Recommended concentration: 0.3-1µg/ml. Primary incubation was 1 hour. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SDCCAG8 |
| Gene ID | 10806 |
| Uniprot ID | SDCG8_HUMAN |
| Accession Number | NP_006633.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | TINDQSQYIHHLEAE |
Additional Info
| Function | Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis. |
| Protein Name | Serologically Defined Colon Cancer Antigen 8Antigen Ny-Co-8Centrosomal Colon Cancer Autoantigen ProteinHcccap |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCilium Basal BodyCell JunctionLocated At The Distal Ends Of Both Centrioles And Colocalizes To Centrosomes Throughout The Cell CycleIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Serologically Defined Colon Cancer Antigen 8 antibodyAnti-Antigen Ny-Co-8 antibodyAnti-Centrosomal Colon Cancer Autoantigen Protein antibodyAnti-Hcccap antibodyAnti-SDCCAG8 antibodyAnti-CCCAP antibodyAnti-NPHP10 antibodyAnti-HSPC085 antibody |
Information sourced from Uniprot.org