| Tissue Specificity | Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors. |
| Function | Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis. |
| Protein Name | Serologically Defined Colon Cancer Antigen 8Antigen Ny-Co-8Centrosomal Colon Cancer Autoantigen ProteinHcccap |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCilium Basal BodyCell JunctionLocated At The Distal Ends Of Both Centrioles And Colocalizes To Centrosomes Throughout The Cell CycleIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Serologically Defined Colon Cancer Antigen 8 antibodyAnti-Antigen Ny-Co-8 antibodyAnti-Centrosomal Colon Cancer Autoantigen Protein antibodyAnti-Hcccap antibodyAnti-SDCCAG8 antibodyAnti-CCCAP antibodyAnti-NPHP10 antibodyAnti-HSPC085 antibody |
Information sourced from Uniprot.org
