Anti-SDCCAG8 antibody (520-600) (STJ94581)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from NY-CO-8. at AA range: 520-600
General Information
| Short Description | Rabbit polyclonal anti-Serologically defined colon cancer antigen 8 (520-600) for use in IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SDCCAG8 |
| Gene ID | 10806 |
| Uniprot ID | SDCG8_HUMAN |
| Immunogen | Synthesized peptide derived from NY-CO-8. at AA range: 520-600 |
| Immunogen Region | 520-600 |
| Specificity | NY-CO-8 Polyclonal Antibody detects endogenous levels of NY-CO-8 protein. |
Additional Info
| Tissue Specificity | Expressed in thymus, prostate, testis, ovary, small intestine, colon, mucosa, colon and renal cancer tumors. |
| Function | Plays a role in the establishment of cell polarity and epithelial lumen formation. Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis. |
| Protein Name | Serologically Defined Colon Cancer Antigen 8Antigen Ny-Co-8Centrosomal Colon Cancer Autoantigen ProteinHcccap |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleCilium Basal BodyCell JunctionLocated At The Distal Ends Of Both Centrioles And Colocalizes To Centrosomes Throughout The Cell CycleIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Serologically Defined Colon Cancer Antigen 8 antibodyAnti-Antigen Ny-Co-8 antibodyAnti-Centrosomal Colon Cancer Autoantigen Protein antibodyAnti-Hcccap antibodyAnti-SDCCAG8 antibodyAnti-CCCAP antibodyAnti-NPHP10 antibodyAnti-HSPC085 antibody |
Information sourced from Uniprot.org