| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCN2B (30-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCN2B |
| Gene ID: |
6327 |
| Uniprot ID: |
SCN2B_HUMAN |
| Immunogen Region: |
30-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-160 of human SCN2B (NP_004579.1). |
| Immunogen Sequence: |
MEVTVPATLNVLNGSDARLP CTFNSCYTVNHKQFSLNWTY QECNNCSEEMFLQFRMKIIN LKLERFQDRVEFSGNPSKYD VSVMLRNVQPEDEGIYNCYI MNPPDRHRGHGKIHLQVLME EPPERDSTVAV |
| Tissue Specificity | Brain specific. |
| Function | Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. |
| Protein Name | Sodium Channel Subunit Beta-2 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Sodium Channel Subunit Beta-2 antibodyAnti-SCN2B antibodyAnti-UNQ326 antibodyAnti-PRO386 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
