| Function | Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8. |
| Protein Name | Sodium Channel Regulatory Subunit Beta-2 |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-5576892Reactome: R-HSA-9717207 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonClusters At The Axon Initial Segment And Node Of RanvierThe Specialized Neuronal Subcellular Domains Involved In Action Potentials Generation And Propagation |
| Alternative Antibody Names | Anti-Sodium Channel Regulatory Subunit Beta-2 antibodyAnti-SCN2B antibodyAnti-UNQ326 antibodyAnti-PRO386 antibody |
Information sourced from Uniprot.org
