Host: |
Rabbit |
Applications: |
WB |
Reactivity: |
Human/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-SASH1 (1-300) is suitable for use in Western Blot research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:500-1:2000 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
SASH1 |
Gene ID: |
23328 |
Uniprot ID: |
SASH1_HUMAN |
Immunogen Region: |
1-300 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SASH1 (NP_056093.3). |
Immunogen Sequence: |
MEDAGAAGPGPEPEPEPEPE PEPAPEPEPEPKPGAGTSEA FSRLWTDVMGILDGSLGNID DLAQQYADYYNTCFSDVCER MEELRKRRVSQDLEVEKPDA SPTSLQLRSQIEESLGFCSA VSTPEVERKNPLHKSNSEDS SVGKGDWKKKNKYFWQNFRK NQKGIMRQTSKGEDVGYVAS EITMSDEERIQLMMMVKEKM ITIEEALARLKEYEAQHRQS AALDPADWPDGSYPTFDGS |
Tissue Specificity | Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes, dermal fibroblasts and melanocytes. |
Function | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis. |
Protein Name | Sam And Sh3 Domain-Containing Protein 1Proline-Glutamate Repeat-Containing Protein |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Sam And Sh3 Domain-Containing Protein 1 antibodyAnti-Proline-Glutamate Repeat-Containing Protein antibodyAnti-SASH1 antibodyAnti-KIAA0790 antibodyAnti-PEPE1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance