| Tissue Specificity | Expressed ubiquitously, with highest levels in lung, placenta, spleen and thymus. Down-regulated in the majority (74%) of breast tumors in comparison with corresponding normal breast epithelial tissues. Expressed in the epidermis, epidermal keratinocytes, dermal fibroblasts and melanocytes. |
| Function | Is a positive regulator of NF-kappa-B signaling downstream of TLR4 activation. It acts as a scaffold molecule to assemble a molecular complex that includes TRAF6, MAP3K7, CHUK and IKBKB, thereby facilitating NF-kappa-B signaling activation. Regulates TRAF6 and MAP3K7 ubiquitination. Involved in the regulation of cell mobility. Regulates lipolysaccharide (LPS)-induced endothelial cell migration. Is involved in the regulation of skin pigmentation through the control of melanocyte migration in the epidermis. |
| Protein Name | Sam And Sh3 Domain-Containing Protein 1Proline-Glutamate Repeat-Containing Protein |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sam And Sh3 Domain-Containing Protein 1 antibodyAnti-Proline-Glutamate Repeat-Containing Protein antibodyAnti-SASH1 antibodyAnti-KIAA0790 antibodyAnti-PEPE1 antibody |
Information sourced from Uniprot.org
