| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-SAP domain-containing ribonucleoprotein (147-196 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SARNP |
| Gene ID: | 84324 |
| Uniprot ID: | SARNP_HUMAN |
| Immunogen Region: | 147-196 aa |
| Specificity: | CIP29 Polyclonal Antibody detects endogenous levels of CIP29 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human HCC1 at the amino acid range 147-196 |
| Function | Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Associates with DDX39B, which facilitates RNA binding of DDX39B and likely plays a role in mRNA export. |
| Protein Name | Sap Domain-Containing Ribonucleoprotein Cytokine-Induced Protein Of 29 Kda Nuclear Protein Hcc-1 Proliferation-Associated Cytokine-Inducible Protein Cip29 |
| Database Links | Reactome: R-HSA-159236 Reactome: R-HSA-72187 Reactome: R-HSA-73856 |
| Cellular Localisation | Nucleus Nucleus Speckle |
| Alternative Antibody Names | Anti-Sap Domain-Containing Ribonucleoprotein antibody Anti-Cytokine-Induced Protein Of 29 Kda antibody Anti-Nuclear Protein Hcc-1 antibody Anti-Proliferation-Associated Cytokine-Inducible Protein Cip29 antibody Anti-SARNP antibody Anti-HCC1 antibody Anti-HSPC316 antibody |
Information sourced from Uniprot.org