| Function | Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. |
| Protein Name | Store-Operated Calcium Entry-Associated Regulatory FactorSarafSoce-Associated Regulatory FactorHbv X-Transactivated Gene 3 ProteinHbv Xag-Transactivated Protein 3Protein Foap-7Transmembrane Protein 66 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinTranslocates To The Endoplasmic Reticulum-Plasma Membrane (Er-Pm) Region In A Stim1-Dependent Manner Following Cytosolic Ca(2+) ElevationIsoform 2: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Store-Operated Calcium Entry-Associated Regulatory Factor antibodyAnti-Saraf antibodyAnti-Soce-Associated Regulatory Factor antibodyAnti-Hbv X-Transactivated Gene 3 Protein antibodyAnti-Hbv Xag-Transactivated Protein 3 antibodyAnti-Protein Foap-7 antibodyAnti-Transmembrane Protein 66 antibodyAnti-SARAF antibodyAnti-TMEM66 antibodyAnti-XTP3 antibodyAnti-HSPC035 antibodyAnti-NPD003 antibodyAnti-PSEC0019 antibodyAnti-UNQ1967 antibodyAnti-PRO4499 antibody |
Information sourced from Uniprot.org
