| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Store-operated calcium entry-associated regulatory factor (277-327 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SARAF |
| Gene ID: | 51669 |
| Uniprot ID: | SARAF_HUMAN |
| Immunogen Region: | 277-327 aa |
| Specificity: | This antibody detects endogenous levels of SARAF at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human SARAF at the amino acid range 277-327 |
| Function | Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. |
| Protein Name | Store-Operated Calcium Entry-Associated Regulatory Factor Saraf Soce-Associated Regulatory Factor Hbv X-Transactivated Gene 3 Protein Hbv Xag-Transactivated Protein 3 Protein Foap-7 Transmembrane Protein 66 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Single-Pass Type I Membrane Protein Translocates To The Endoplasmic Reticulum-Plasma Membrane (Er-Pm) Region In A Stim1-Dependent Manner Following Cytosolic Ca(2+) Elevation Isoform 2: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Store-Operated Calcium Entry-Associated Regulatory Factor antibody Anti-Saraf antibody Anti-Soce-Associated Regulatory Factor antibody Anti-Hbv X-Transactivated Gene 3 Protein antibody Anti-Hbv Xag-Transactivated Protein 3 antibody Anti-Protein Foap-7 antibody Anti-Transmembrane Protein 66 antibody Anti-SARAF antibody Anti-TMEM66 antibody Anti-XTP3 antibody Anti-HSPC035 antibody Anti-NPD003 antibody Anti-PSEC0019 antibody Anti-UNQ1967 antibody Anti-PRO4499 antibody |
Information sourced from Uniprot.org