Anti-SARAF antibody (277-327 aa) (STJ193854)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SARAF at the amino acid range 277-327
General Information
| Short Description | Rabbit polyclonal anti-Store-operated calcium entry-associated regulatory factor (277-327 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SARAF |
| Gene ID | 51669 |
| Uniprot ID | SARAF_HUMAN |
| Immunogen | Synthesized peptide derived from the human SARAF at the amino acid range 277-327 |
| Immunogen Region | 277-327 aa |
| Specificity | This antibody detects endogenous levels of SARAF at Human/Mouse/Rat |
Additional Info
| Function | Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. |
| Protein Name | Store-Operated Calcium Entry-Associated Regulatory FactorSarafSoce-Associated Regulatory FactorHbv X-Transactivated Gene 3 ProteinHbv Xag-Transactivated Protein 3Protein Foap-7Transmembrane Protein 66 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinTranslocates To The Endoplasmic Reticulum-Plasma Membrane (Er-Pm) Region In A Stim1-Dependent Manner Following Cytosolic Ca(2+) ElevationIsoform 2: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Store-Operated Calcium Entry-Associated Regulatory Factor antibodyAnti-Saraf antibodyAnti-Soce-Associated Regulatory Factor antibodyAnti-Hbv X-Transactivated Gene 3 Protein antibodyAnti-Hbv Xag-Transactivated Protein 3 antibodyAnti-Protein Foap-7 antibodyAnti-Transmembrane Protein 66 antibodyAnti-SARAF antibodyAnti-TMEM66 antibodyAnti-XTP3 antibodyAnti-HSPC035 antibodyAnti-NPD003 antibodyAnti-PSEC0019 antibodyAnti-UNQ1967 antibodyAnti-PRO4499 antibody |
Information sourced from Uniprot.org