| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Store-operated calcium entry-associated regulatory factor (277-327 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SARAF |
| Gene ID: |
51669 |
| Uniprot ID: |
SARAF_HUMAN |
| Immunogen Region: |
277-327 aa |
| Specificity: |
This antibody detects endogenous levels of SARAF at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human SARAF at the amino acid range 277-327 |
| Function | Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. |
| Protein Name | Store-Operated Calcium Entry-Associated Regulatory FactorSarafSoce-Associated Regulatory FactorHbv X-Transactivated Gene 3 ProteinHbv Xag-Transactivated Protein 3Protein Foap-7Transmembrane Protein 66 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinTranslocates To The Endoplasmic Reticulum-Plasma Membrane (Er-Pm) Region In A Stim1-Dependent Manner Following Cytosolic Ca(2+) ElevationIsoform 2: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Store-Operated Calcium Entry-Associated Regulatory Factor antibodyAnti-Saraf antibodyAnti-Soce-Associated Regulatory Factor antibodyAnti-Hbv X-Transactivated Gene 3 Protein antibodyAnti-Hbv Xag-Transactivated Protein 3 antibodyAnti-Protein Foap-7 antibodyAnti-Transmembrane Protein 66 antibodyAnti-SARAF antibodyAnti-TMEM66 antibodyAnti-XTP3 antibodyAnti-HSPC035 antibodyAnti-NPD003 antibodyAnti-PSEC0019 antibodyAnti-UNQ1967 antibodyAnti-PRO4499 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
