Anti-SAP30L antibody (C-Term) (STJA0005776)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acids from the C-terminal region of human SAP30L.
General Information
| Short Description | Rabbit polyclonal anti-SAP30L (C-Term) for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | PBS + 0.02% NaN3 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SAP30L |
| Gene ID | 79685 |
| Uniprot ID | SP30L_HUMAN |
| Immunogen | Synthetic peptide corresponding to amino acids from the C-terminal region of human SAP30L. |
| Immunogen Region | C-Term |
| Specificity | Reacts with the C-terminal region of human SAP30L. Detects wild-type transfected hSAP30L or GST-hSAP30L fusion protein as well as endogenous hSAP30L in human cell lines (e.g., HEK293 and MCF-7 cells). Detects wild-type transfected hSAP30L or GST-hSAP |
Additional Info
| Function | Isoform 1: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes. Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus. Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA. Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import. Isoform 2: Functions as a transcription repressor.isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. Isoform 3: Functions as a transcription repressor.its activity is marginally lower than that of isoform 1. |
| Protein Name | Histone Deacetylase Complex Subunit Sap30lHcv Non-Structural Protein 4a-Transactivated Protein 2Sin3 Corepressor Complex Subunit Sap30lSin3-Associated Protein P30-Like |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427413Reactome: R-HSA-9679191 |
| Cellular Localisation | Isoform 1: NucleusNucleolusIsoform 2: NucleusIsoform 3: Nucleus |
| Alternative Antibody Names | Anti-Histone Deacetylase Complex Subunit Sap30l antibodyAnti-Hcv Non-Structural Protein 4a-Transactivated Protein 2 antibodyAnti-Sin3 Corepressor Complex Subunit Sap30l antibodyAnti-Sin3-Associated Protein P30-Like antibodyAnti-SAP30L antibodyAnti-NS4ATP2 antibody |
Information sourced from Uniprot.org