Anti-S100A1 antibody (1-94) (STJ11103849)

Name: Anti-S100A1 antibody (1-94) (STJ11103849)
SKU: STJ11103849
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103849

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Short Description	Rabbit polyclonal Protein S100-A1 (1-94) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	IF/ICC:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	S100A1
Gene ID	6271
Uniprot ID	S10A1_HUMAN
Immunogen Region	1-94
Immunogen Sequence	MGSELETAMETLINVFHAHS GKEGDKYKLSKKELKELLQT ELSGFLDAQKDVDAVDKVMK ELDENGDGEVDFQEYVVLVA ALTVACNNFFWENS
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-94 of human S100/S100A1 (NP_006262.1).

Tissue Specificity	Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.
Post Translational Modifications	Glutathionylated.glutathionylation increases affinity to calcium about 10-fold.
Function	Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole.
Protein Name	Protein S100-A1 S-100 Protein Alpha Chain S-100 Protein Subunit Alpha S100 Calcium-Binding Protein A1
Database Links	Reactome: R-HSA-1236974 Reactome: R-HSA-166058 Reactome: R-HSA-5602498 Reactome: R-HSA-5603041 Reactome: R-HSA-5686938
Cellular Localisation	Cytoplasm Sarcoplasmic Reticulum Mitochondrion
Alternative Antibody Names	Anti-Protein S100-A1 antibody Anti-S-100 Protein Alpha Chain antibody Anti-S-100 Protein Subunit Alpha antibody Anti-S100 Calcium-Binding Protein A1 antibody Anti-S100A1 antibody Anti-S100A antibody

Information sourced from Uniprot.org