| Tissue Specificity | Down-regulated in breast cancer tissues and in several breast cancer cell lines (at protein level). Widely expressed with highest levels in lymphoid tissues and placenta. |
| Post Translational Modifications | Monoubiquitinated. |
| Function | Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones.it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites. Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3. |
| Protein Name | Ring1 And Yy1-Binding ProteinApoptin-Associating Protein 1Apap-1Death Effector Domain-Associated FactorDed-Associated FactorYy1 And E4tf1-Associated Factor 1 |
| Database Links | Reactome: R-HSA-8939243Reactome: R-HSA-8953750 |
| Cellular Localisation | NucleusCytoplasmNucleoplasmPrimarily Found In The NucleusDetected In A Punctate Pattern Likely To Represent Polycomb Group (Pcg) Bodies |
| Alternative Antibody Names | Anti-Ring1 And Yy1-Binding Protein antibodyAnti-Apoptin-Associating Protein 1 antibodyAnti-Apap-1 antibodyAnti-Death Effector Domain-Associated Factor antibodyAnti-Ded-Associated Factor antibodyAnti-Yy1 And E4tf1-Associated Factor 1 antibodyAnti-RYBP antibodyAnti-DEDAF antibodyAnti-YEAF1 antibody |
Information sourced from Uniprot.org
