| Short Description : | Rabbit polyclonal RRAS2 (1-204) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RRAS2 |
| Gene ID: | 22800 |
| Uniprot ID: | RRAS2_HUMAN |
| Immunogen Region: | 1-204 |
| Immunogen Sequence: | MAAAGWRDGSGQEKYRLVVV GGGGVGKSALTIQFIQSYFV TDYDPTIEDSYTKQCVIDDR AARLDILDTAGQEEFGAMRE QYMRTGEGFLLVFSVTDRGS FEEIYKFQRQILRVKDRDEF PMILIGNKADLDHQRQVTQE EGQQLARQLKVTYMEASAKI RMNVDQAFHELVRVIRKFQE QECPPSPEPTRKEKDKKGCH CVIF |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-204A of human RRAS2 (NP_036382.2). |
| Tissue Specificity | Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver.low levels in brain, kidney, and pancreas. |
| Post Translational Modifications | May be post-translationally modified by both palmitoylation and polyisoprenylation. Fatty-acylation at Lys-192, Lys-194.lys-196 and Lys-197 is required for localization to the plasma membrane and activity. Defatty-acylated by SIRT6, affecting its localization to the plasma membrane. |
| Function | GTP-binding protein with GTPase activity, involved in the regulation of MAPK signaling pathway and thereby controlling multiple cellular processes. Regulates craniofacial development. |
| Protein Name | Ras-Related Protein R-Ras2Ras-Like Protein Tc21Teratocarcinoma Oncogene |
| Database Links | Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Ras-Related Protein R-Ras2 antibodyAnti-Ras-Like Protein Tc21 antibodyAnti-Teratocarcinoma Oncogene antibodyAnti-RRAS2 antibodyAnti-TC21 antibody |
Information sourced from Uniprot.org
