| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RRAS2 (1-204) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RRAS2 |
| Gene ID: |
22800 |
| Uniprot ID: |
RRAS2_HUMAN |
| Immunogen Region: |
1-204 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-204A of human RRAS2 (NP_036382.2). |
| Immunogen Sequence: |
MAAAGWRDGSGQEKYRLVVV GGGGVGKSALTIQFIQSYFV TDYDPTIEDSYTKQCVIDDR AARLDILDTAGQEEFGAMRE QYMRTGEGFLLVFSVTDRGS FEEIYKFQRQILRVKDRDEF PMILIGNKADLDHQRQVTQE EGQQLARQLKVTYMEASAKI RMNVDQAFHELVRVIRKFQE QECPPSPEPTRKEKDKKGCH CVIF |
| Tissue Specificity | Ubiquitously present in all tissues examined, with the highest levels in heart, placenta, and skeletal muscle. Moderate levels in lung and liver.low levels in brain, kidney, and pancreas. |
| Post Translational Modifications | May be post-translationally modified by both palmitoylation and polyisoprenylation. Fatty-acylation at Lys-192, Lys-194.lys-196 and Lys-197 is required for localization to the plasma membrane and activity. Defatty-acylated by SIRT6, affecting its localization to the plasma membrane. |
| Function | GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes. Involved in the regulation of MAPK signaling pathway. Regulation of craniofacial development. |
| Protein Name | Ras-Related Protein R-Ras2Ras-Like Protein Tc21Teratocarcinoma Oncogene |
| Database Links | Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Ras-Related Protein R-Ras2 antibodyAnti-Ras-Like Protein Tc21 antibodyAnti-Teratocarcinoma Oncogene antibodyAnti-RRAS2 antibodyAnti-TC21 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
