| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RPSA (1-295) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RPSA |
| Gene ID: |
3921 |
| Uniprot ID: |
RSSA_HUMAN |
| Immunogen Region: |
1-295 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human 67kDa Laminin Receptor (NP_002286.2). |
| Immunogen Sequence: |
MSGALDVLQMKEEDVLKFLA AGTHLGGTNLDFQMEQYIYK RKSDGIYIINLKRTWEKLLL AARAIVAIENPADVSVISSR NTGQRAVLKFAAATGATPIA GRFTPGTFTNQIQAAFREPR LLVVTDPRADHQPLTEASYV NLPTIALCNTDSPLRYVDIA IPCNNKGAHSVGLMWWMLAR EVLRMRGTISREHPWEVMPD LYFYRDPEEIEKEEQAAAEK AVTKEEFQGEWTAPAPEFT |
| Post Translational Modifications | Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. |
| Function | Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9. (Microbial infection) Acts as a receptor for the Dengue virus. (Microbial infection) Acts as a receptor for the Sindbis virus. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus. (Microbial infection) Acts as a receptor for the pathogenic prion protein. (Microbial infection) Acts as a receptor for bacteria. |
| Protein Name | Small Ribosomal Subunit Protein Us237 Kda Laminin Receptor Precursor37lrp37/67 Kda Laminin ReceptorLrp/Lr40s Ribosomal Protein Sa67 Kda Laminin Receptor67lrColon Carcinoma Laminin-Binding ProteinLaminin Receptor 1LamrLaminin-Binding Protein Precursor P40Lbp/P40Multidrug Resistance-Associated Protein Mgr1-AgNem/1chd4 |
| Database Links | Reactome: R-HSA-156827Reactome: R-HSA-156902Reactome: R-HSA-1799339Reactome: R-HSA-192823Reactome: R-HSA-2408557Reactome: R-HSA-6791226Reactome: R-HSA-72649Reactome: R-HSA-72689Reactome: R-HSA-72695Reactome: R-HSA-72702Reactome: R-HSA-72706Reactome: R-HSA-72764Reactome: R-HSA-9010553Reactome: R-HSA-9633012Reactome: R-HSA-9735869Reactome: R-HSA-9754678Reactome: R-HSA-975956Reactome: R-HSA-975957 |
| Cellular Localisation | Cell MembraneCytoplasmNucleus67lr Is Found At The Surface Of The Plasma MembraneWith Its C-Terminal Laminin-Binding Domain Accessible To Extracellular Ligands37lrp Is Found At The Cell SurfaceIn The Cytoplasm And In The NucleusColocalizes With Ppp1r16b In The Cell Membrane |
| Alternative Antibody Names | Anti-Small Ribosomal Subunit Protein Us2 antibodyAnti-37 Kda Laminin Receptor Precursor antibodyAnti-37lrp antibodyAnti-37/67 Kda Laminin Receptor antibodyAnti-Lrp/Lr antibodyAnti-40s Ribosomal Protein Sa antibodyAnti-67 Kda Laminin Receptor antibodyAnti-67lr antibodyAnti-Colon Carcinoma Laminin-Binding Protein antibodyAnti-Laminin Receptor 1 antibodyAnti-Lamr antibodyAnti-Laminin-Binding Protein Precursor P40 antibodyAnti-Lbp/P40 antibodyAnti-Multidrug Resistance-Associated Protein Mgr1-Ag antibodyAnti-Nem/1chd4 antibodyAnti-RPSA antibodyAnti-LAMBR antibodyAnti-LAMR1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
