Anti-RPAP2 antibody (1-612) (STJ11100451)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RPAP2 (1-612) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RPAP2 |
| Gene ID | 79871 |
| Uniprot ID | RPAP2_HUMAN |
| Immunogen Region | 1-612 |
| Immunogen Sequence | MADFAGPSSAGRKAGAPRCS RKAAGTKQTSTLKQEDASKR KAELEAAVRKKIEFERKALH IVEQLLEENITEEFLMECGR FITPAHYSDVVDERSIVKLC GYPLCQKKLGIVPKQKYKIS TKTNKVYDITERKSFCSNFC YQASKFFEAQIPKTPVWVRE EERHPDFQLLKEEQSGHSGE EVQLCSKAIKTSDIDNPSHF EKQYESSSSSTHSDSSSDNE QDFVSSILPGNRPNSTNIR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-612 of human RPAP2 (Q8IXW5). |
Additional Info
| Function | Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis. |
| Protein Name | Putative Rna Polymerase Ii Subunit B1 Ctd Phosphatase Rpap2Rna Polymerase Ii-Associated Protein 2 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Cytoplasm And The Nucleus In A Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-Putative Rna Polymerase Ii Subunit B1 Ctd Phosphatase Rpap2 antibodyAnti-Rna Polymerase Ii-Associated Protein 2 antibodyAnti-RPAP2 antibodyAnti-C1orf82 antibody |
Information sourced from Uniprot.org