| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RPAP2 (1-612) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RPAP2 |
| Gene ID: |
79871 |
| Uniprot ID: |
RPAP2_HUMAN |
| Immunogen Region: |
1-612 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-612 of human RPAP2 (Q8IXW5). |
| Immunogen Sequence: |
MADFAGPSSAGRKAGAPRCS RKAAGTKQTSTLKQEDASKR KAELEAAVRKKIEFERKALH IVEQLLEENITEEFLMECGR FITPAHYSDVVDERSIVKLC GYPLCQKKLGIVPKQKYKIS TKTNKVYDITERKSFCSNFC YQASKFFEAQIPKTPVWVRE EERHPDFQLLKEEQSGHSGE EVQLCSKAIKTSDIDNPSHF EKQYESSSSSTHSDSSSDNE QDFVSSILPGNRPNSTNIR |
| Function | Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis. |
| Protein Name | Putative Rna Polymerase Ii Subunit B1 Ctd Phosphatase Rpap2Rna Polymerase Ii-Associated Protein 2 |
| Database Links | Reactome: R-HSA-6807505 |
| Cellular Localisation | CytoplasmNucleusShuttles Between The Cytoplasm And The Nucleus In A Crm1-Dependent Manner |
| Alternative Antibody Names | Anti-Putative Rna Polymerase Ii Subunit B1 Ctd Phosphatase Rpap2 antibodyAnti-Rna Polymerase Ii-Associated Protein 2 antibodyAnti-RPAP2 antibodyAnti-C1orf82 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
