Anti-RNLS antibody (STJA0007184)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RENALASE
General Information
| Short Description | Rabbit polyclonal anti-Renalase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNLS |
| Gene ID | 55328 |
| Uniprot ID | RNLS_HUMAN |
| Immunogen | Synthesized peptide derived from human RENALASE |
| Specificity | This antibody detects endogenous levels of RENALASE at Human, Mouse, Rat |
Additional Info
| Function | Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. |
| Protein Name | RenalaseMonoamine Oxidase-CMao-C |
| Database Links | Reactome: R-HSA-197264 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Renalase antibodyAnti-Monoamine Oxidase-C antibodyAnti-Mao-C antibodyAnti-RNLS antibodyAnti-C10orf59 antibody |
Information sourced from Uniprot.org