Anti-RNASET2 antibody (STJA0007365)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RNase T2
General Information
| Short Description | Rabbit polyclonal anti-Ribonuclease T2 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RNASET2 |
| Gene ID | 8635 |
| Uniprot ID | RNT2_HUMAN |
| Immunogen | Synthesized peptide derived from human RNase T2 |
| Specificity | This antibody detects endogenous levels of RNase T2 at Human, Mouse |
Additional Info
| Function | Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs. |
| Protein Name | Ribonuclease T2Ribonuclease 6 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedLysosome LumenEndoplasmic Reticulum LumenMitochondrion Intermembrane SpaceFull-Length Rnaset2 Is Found In The Endoplasmic Reticulum While Smaller Rnaset2 Proteolytic Products Are Found In The Lysosome Fraction |
| Alternative Antibody Names | Anti-Ribonuclease T2 antibodyAnti-Ribonuclease 6 antibodyAnti-RNASET2 antibodyAnti-RNASE6PL antibody |
Information sourced from Uniprot.org