Anti-RNASET2 antibody (STJA0007365)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-2000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	RNASET2
Gene ID:	8635
Uniprot ID:	RNT2_HUMAN
Specificity:	This antibody detects endogenous levels of RNase T2 at Human, Mouse
Immunogen:	Synthesized peptide derived from human RNase T2

Function	Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
Protein Name	Ribonuclease T2 Ribonuclease 6
Database Links	Reactome: R-HSA-6798695
Cellular Localisation	Secreted Lysosome Lumen Endoplasmic Reticulum Lumen Mitochondrion Intermembrane Space Full-Length Rnaset2 Is Found In The Endoplasmic Reticulum While Smaller Rnaset2 Proteolytic Products Are Found In The Lysosome Fraction
Alternative Antibody Names	Anti-Ribonuclease T2 antibody Anti-Ribonuclease 6 antibody Anti-RNASET2 antibody Anti-RNASE6PL antibody

Information sourced from Uniprot.org

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