| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RHOT1 (310-590) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RHOT1 |
| Gene ID: |
55288 |
| Uniprot ID: |
MIRO1_HUMAN |
| Immunogen Region: |
310-590 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 310-590 of human RHOT1/MIRO1 (NP_060777.3). |
| Immunogen Sequence: |
QSTFDKHDLDRDCALSPDEL KDLFKVFPYIPWGPDVNNTV CTNERGWITYQGFLSQWTLT TYLDVQRCLEYLGYLGYSIL TEQESQASAVTVTRDKKIDL QKKQTQRNVFRCNVIGVKNC GKSGVLQALLGRNLMRQKKI REDHKSYYAINTVYVYGQEK YLLLHDISESEFLTEAEIIC DVVCLVYDVSNPKSFEYCAR IFKQHFMDSRIPCLIVAAKS DLHEVKQEYSISPTDFCRK |
| Tissue Specificity | Ubiquitously expressed. Expressed at high level in heart and skeletal muscle. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Promotes mitochondrial fission during high calcium conditions. |
| Protein Name | Mitochondrial Rho Gtpase 1Miro-1Hmiro-1Rac-Gtp-Binding Protein-Like ProteinRas Homolog Gene Family Member T1 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-9013425 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Iv Membrane ProteinColocalizes With Mgarp And Rhot2 At The Mitochondria |
| Alternative Antibody Names | Anti-Mitochondrial Rho Gtpase 1 antibodyAnti-Miro-1 antibodyAnti-Hmiro-1 antibodyAnti-Rac-Gtp-Binding Protein-Like Protein antibodyAnti-Ras Homolog Gene Family Member T1 antibodyAnti-RHOT1 antibodyAnti-ARHT1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
