Anti-RHOBTB2 antibody (320-480) (STJ11100386)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RHOBTB2 (320-480) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RHOBTB2 |
| Gene ID | 23221 |
| Uniprot ID | RHBT2_HUMAN |
| Immunogen Region | 320-480 |
| Immunogen Sequence | MDLSEGELGGPSEPGGTHPE DHQGHSDQHHHHHHHHHGRD FLLRAASFDVCESVDEAGGS GPAGLRASTSDGILRGNGTG YLPGRGRVLSSWSRAFVSIQ EEMAEDPLTYKSRLMVVVKM DSSIQPGPFRAVLKYLYTGE LDENERDLMHIAHIAELLEV F |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 320-480 of human RHOBTB2 (NP_001153508.1). |
Additional Info
| Tissue Specificity | Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain. |
| Post Translational Modifications | Autoubiquitinated by RHOBTB2-CUL3-RBX1 ubiquitin ligase complex. |
| Function | Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation. |
| Protein Name | Rho-Related Btb Domain-Containing Protein 2Deleted In Breast Cancer 2 Gene ProteinP83 |
| Database Links | Reactome: R-HSA-9013418 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Rho-Related Btb Domain-Containing Protein 2 antibodyAnti-Deleted In Breast Cancer 2 Gene Protein antibodyAnti-P83 antibodyAnti-RHOBTB2 antibodyAnti-DBC2 antibodyAnti-KIAA0717 antibody |
Information sourced from Uniprot.org