| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RHOBTB2 |
| Gene ID: | 23221 |
| Uniprot ID: | RHBT2_HUMAN |
| Immunogen Region: | 320-480 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-480 of human RHOBTB2 (NP_001153508.1). |
| Immunogen Sequence: | MDLSEGELGGPSEPGGTHPE DHQGHSDQHHHHHHHHHGRD FLLRAASFDVCESVDEAGGS GPAGLRASTSDGILRGNGTG YLPGRGRVLSSWSRAFVSIQ EEMAEDPLTYKSRLMVVVKM DSSIQPGPFRAVLKYLYTGE LDENERDLMHIAHIAELLEV F |
| Tissue Specificity | Ubiquitous, with highest levels in neural tissues. Expression is also detected in fetal lung, heart, and brain. |
| Post Translational Modifications | Autoubiquitinated by RHOBTB2-CUL3-RBX1 ubiquitin ligase complex. |
| Function | Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation. |
| Protein Name | Rho-Related Btb Domain-Containing Protein 2Deleted In Breast Cancer 2 Gene ProteinP83 |
| Database Links | Reactome: R-HSA-9013418 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Rho-Related Btb Domain-Containing Protein 2 antibodyAnti-Deleted In Breast Cancer 2 Gene Protein antibodyAnti-P83 antibodyAnti-RHOBTB2 antibodyAnti-DBC2 antibodyAnti-KIAA0717 antibody |
Information sourced from Uniprot.org
