Anti-RGMB antibody (Internal Region) (STJ13101945)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from internal region of mature mouse Repulsive guidance molecule B (RGMB, DRAGON) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-RGMB (Internal Region) for use in IHC and WB in Mouse and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Rgmb |
| Gene ID | 68799 |
| Uniprot ID | RGMB_MOUSE |
| Immunogen | A synthetic peptide from internal region of mature mouse Repulsive guidance molecule B (RGMB, DRAGON) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | Internal Region |
| Specificity | Specific for RGMB. |
Additional Info
| Post Translational Modifications | GPI-anchored. Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. |
| Function | Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth. |
| Protein Name | Repulsive Guidance Molecule BDrg11-Responsive Axonal Guidance And Outgrowth Of NeuriteDragon |
| Database Links | |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane Raft |
| Alternative Antibody Names | Anti-Repulsive Guidance Molecule B antibodyAnti-Drg11-Responsive Axonal Guidance And Outgrowth Of Neurite antibodyAnti-Dragon antibodyAnti-Rgmb antibody |
Information sourced from Uniprot.org