Anti-REXO2 antibody (26-237) (STJ118253)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal REXO2 (26-237) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | REXO2 |
| Gene ID | 25996 |
| Uniprot ID | ORN_HUMAN |
| Immunogen Region | 26-237 |
| Immunogen Sequence | VREGGAAMAAGESMAQRMVW VDLEMTGLDIEKDQIIEMAC LITDSDLNILAEGPNLIIKQ PDELLDSMSDWCKEHHGKSG LTKAVKESTITLQQAEYEFL SFVRQQTPPGLCPLAGNSVH EDKKFLDKYMPQFMKHLHYR IIDVSTVKELCRRWYPEEYE FAPKKAASHRALDDISESIK ELQFYRNNIFKKKIDEKKRK IIENGENEKTVS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 26-237 of human REXO2 (NP_056338.2). |
Additional Info
| Tissue Specificity | Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus. |
| Function | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development. Isoform 3: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. |
| Protein Name | Oligoribonuclease - MitochondrialRna Exonuclease 2 HomologSmall Fragment Nuclease |
| Database Links | Reactome: R-HSA-9836573 |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MatrixMitochondrionCytoplasmNucleusIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Oligoribonuclease - Mitochondrial antibodyAnti-Rna Exonuclease 2 Homolog antibodyAnti-Small Fragment Nuclease antibodyAnti-REXO2 antibodyAnti-SFN antibodyAnti-SMFN antibodyAnti-CGI-114 antibody |
Information sourced from Uniprot.org