| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-REXO2 (26-237) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
REXO2 |
| Gene ID: |
25996 |
| Uniprot ID: |
ORN_HUMAN |
| Immunogen Region: |
26-237 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 26-237 of human REXO2 (NP_056338.2). |
| Immunogen Sequence: |
VREGGAAMAAGESMAQRMVW VDLEMTGLDIEKDQIIEMAC LITDSDLNILAEGPNLIIKQ PDELLDSMSDWCKEHHGKSG LTKAVKESTITLQQAEYEFL SFVRQQTPPGLCPLAGNSVH EDKKFLDKYMPQFMKHLHYR IIDVSTVKELCRRWYPEEYE FAPKKAASHRALDDISESIK ELQFYRNNIFKKKIDEKKRK IIENGENEKTVS |
| Tissue Specificity | Highly expressed in the heart and at lower levels in the lymph nodes, brain, lung, liver, spleen and thymus. |
| Function | 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development. Isoform 3: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. |
| Protein Name | Oligoribonuclease - MitochondrialRna Exonuclease 2 HomologSmall Fragment Nuclease |
| Cellular Localisation | Mitochondrion Intermembrane SpaceMitochondrion MatrixMitochondrionCytoplasmNucleusIsoform 3: Cytoplasm |
| Alternative Antibody Names | Anti-Oligoribonuclease - Mitochondrial antibodyAnti-Rna Exonuclease 2 Homolog antibodyAnti-Small Fragment Nuclease antibodyAnti-REXO2 antibodyAnti-SFN antibodyAnti-SMFN antibodyAnti-CGI-114 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
