| Function | Transcriptional regulator with bimodal DNA-binding specificity. Binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' and also binds to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. May contribute to the repression of target genes of the Wnt signaling pathway. May also activate transcription of a subset of target genes by the recruitment of CTNND2. Represses expression of MMP7 in conjunction with transcriptional corepressors CBFA2T3, CBFA2T2 and RUNX1T1. |
| Protein Name | Transcriptional Regulator KaisoZinc Finger And Btb Domain-Containing Protein 33 |
| Cellular Localisation | NucleusCytoplasmAlso Cytoplasmic In Cells Grown At High Densities |
| Alternative Antibody Names | Anti-Transcriptional Regulator Kaiso antibodyAnti-Zinc Finger And Btb Domain-Containing Protein 33 antibodyAnti-ZBTB33 antibodyAnti-KAISO antibodyAnti-ZNF348 antibody |
Information sourced from Uniprot.org
