Polyclonal antibodies

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What are polyclonal antibodies?

Polyclonal antibodies are secreted from different B cell lineages in the body of a suitable mammal, like a mouse, rabbit or goat. Due to their origin, polyclonal antibodies can bind to different epitopes of the same antigen.



To produce them, an animal is immunised over a period of several weeks, resulting in the B-lymphocytes producing immunoglobulins. When the immunisation cycle is completed, the antibodies can be either obtained from the serum or can be further purified from the rest of the serum proteins.



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