Anti-Recombinant-PDE10A antibody (439-779 aa) [S4945RM] (STJ11104945)

Name: Anti-Recombinant-PDE10A antibody (439-779 aa) [S4945RM] (STJ11104945)
SKU: STJ11104945
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11104945

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Short Description	Rabbit monoclonal Recombinant-Camp And Camp-Inhibited Cgmp 3 5 Cyclic Phosphodiesterase 10a (439-779 aa) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S4945RM
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	PDE10A
Gene ID	10846
Uniprot ID	PDE10_HUMAN
Immunogen Region	439-779 aa
Immunogen Sequence	SICTSEEWQGLMQFTLPVRL CKEIELFHFDIGPFENMWPG IFVYMVHRSCGTSCFELEKL CRFIMSVKKNYRRVPYHNWK HAVTVAHCMYAILQNNHTLF TDLERKGLLIACLCHDLDHR GFSNSYLQKFDHPLAALYST STMEQHHFSQTVSILQLEGH NIFSTLSSSEYEQVLEIIRK AIIATDLALYFGNRKQLEEM YQTGSLNLNNQSHRDRVIGL MMTACDLCSVTKLWPVTKL
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 439-779 of human PDE10A. (NP_006652.1).

Tissue Specificity	Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Post Translational Modifications	Isoform PDE10A2: Phosphorylated on Thr-16.
Function	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
Protein Name	Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a
Database Links	Reactome: R-HSA-418457 Reactome: R-HSA-418555
Cellular Localisation	Cytoplasm Cytosol
Alternative Antibody Names	Anti-Camp And Camp-Inhibited Cgmp 3' -5'-Cyclic Phosphodiesterase 10a antibody Anti-PDE10A antibody

Information sourced from Uniprot.org