Anti-Recombinant-ALKBH4 antibody [RM2M97] (STJA0026160)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal anti-Recombinant-Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4 for use in IP and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | RM2M97 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Protein A/G purified from cell culture supernatant |
| Dilution Range | IP: 1:20, WB: 1:500-1:1000 |
| Formulation | 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Target Information
| Gene Symbol | ALKBH4 |
| Gene ID | 54784 |
| Uniprot ID | ALKB4_HUMAN |
Additional Info
| Function | Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing. |
| Protein Name | Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4Alkylated Dna Repair Protein Alkb Homolog 4Dna N6-Methyl Adenine Demethylase Alkbh4Lysine-Specific Demethylase Alkbh4 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNucleolusMidbodyAssociates With The Contractile Ring And Midbody |
| Alternative Antibody Names | Anti-Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4 antibodyAnti-Alkylated Dna Repair Protein Alkb Homolog 4 antibodyAnti-Dna N6-Methyl Adenine Demethylase Alkbh4 antibodyAnti-Lysine-Specific Demethylase Alkbh4 antibodyAnti-ALKBH4 antibodyAnti-ABH4 antibody |
Information sourced from Uniprot.org