Anti-RDH12 antibody (STJA0009236)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RDH12
General Information
| Short Description | Rabbit polyclonal anti-Retinol dehydrogenase 12 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RDH12 |
| Gene ID | 145226 |
| Uniprot ID | RDH12_HUMAN |
| Immunogen | Synthesized peptide derived from human RDH12 |
| Specificity | This antibody detects endogenous levels of RDH12 at Human, Mouse |
Additional Info
| Function | Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids. |
| Protein Name | Retinol Dehydrogenase 12All-Trans And 9-Cis Retinol DehydrogenaseShort Chain Dehydrogenase/Reductase Family 7c Member 2 |
| Database Links | Reactome: R-HSA-2453902Reactome: R-HSA-9918440 |
| Cellular Localisation | Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Retinol Dehydrogenase 12 antibodyAnti-All-Trans And 9-Cis Retinol Dehydrogenase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 7c Member 2 antibodyAnti-RDH12 antibodyAnti-SDR7C2 antibody |
Information sourced from Uniprot.org