| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-RBBP7 (1-230) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:100-1:500IHC-P 1:50-1:200IF/ICC 1:50-1:200ChIP 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RBBP7 |
| Gene ID: | 5931 |
| Uniprot ID: | RBBP7_HUMAN |
| Immunogen Region: | 1-230 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RbAp46/RBBP7 (NP_002884.1). |
| Immunogen Sequence: | MASKEMFEDTVEERVINEEY KIWKKNTPFLYDLVMTHALQ WPSLTVQWLPEVTKPEGKDY ALHWLVLGTHTSDEQNHLVV ARVHIPNDDAQFDASHCDSD KGEFGGFGSVTGKIECEIKI NHEGEVNRARYMPQNPHIIA TKTPSSDVLVFDYTKHPAKP DPSGECNPDLRLRGHQKEGY GLSWNSNLSGHLLSASDDHT VCLWDINAGPKEGKIVDAKA IFTGHSAVVE |
| Function | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication.the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression.the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling.and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development.and the NURF (nucleosome remodeling factor) complex. |
| Protein Name | Histone-Binding Protein Rbbp7Histone Acetyltransferase Type B Subunit 2Nucleosome-Remodeling Factor Subunit Rbap46Retinoblastoma-Binding Protein 7Rbbp-7Retinoblastoma-Binding Protein P46 |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214815Reactome: R-HSA-3214841Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-427389Reactome: R-HSA-5617472Reactome: R-HSA-606279Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-8951664Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9679191Reactome: R-HSA-9710421 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Histone-Binding Protein Rbbp7 antibodyAnti-Histone Acetyltransferase Type B Subunit 2 antibodyAnti-Nucleosome-Remodeling Factor Subunit Rbap46 antibodyAnti-Retinoblastoma-Binding Protein 7 antibodyAnti-Rbbp-7 antibodyAnti-Retinoblastoma-Binding Protein P46 antibodyAnti-RBBP7 antibodyAnti-RBAP46 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
