Anti-RBBP7 antibody (1-230) (STJ115417)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RBBP7 (1-230) antibody for use in WB, IHC-P, IF, ICC, ELISA and ChIP in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA/ChIP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.ChIP:5 Mu g antibody for 10 Mu g-15 Mu g of Chromat |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RBBP7 |
| Gene ID | 5931 |
| Uniprot ID | RBBP7_HUMAN |
| Immunogen Region | 1-230 |
| Immunogen Sequence | MASKEMFEDTVEERVINEEY KIWKKNTPFLYDLVMTHALQ WPSLTVQWLPEVTKPEGKDY ALHWLVLGTHTSDEQNHLVV ARVHIPNDDAQFDASHCDSD KGEFGGFGSVTGKIECEIKI NHEGEVNRARYMPQNPHIIA TKTPSSDVLVFDYTKHPAKP DPSGECNPDLRLRGHQKEGY GLSWNSNLSGHLLSASDDHT VCLWDINAGPKEGKIVDAKA IFTGHSAVVE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human RbAp46/RBBP7 (NP_002884.1). |
Additional Info
| Function | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication.the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression.the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling.and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development.and the NURF (nucleosome remodeling factor) complex. |
| Protein Name | Histone-Binding Protein Rbbp7Histone Acetyltransferase Type B Subunit 2Nucleosome-Remodeling Factor Subunit Rbap46Retinoblastoma-Binding Protein 7Rbbp-7Retinoblastoma-Binding Protein P46 |
| Database Links | Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214815Reactome: R-HSA-3214841Reactome: R-HSA-3214847Reactome: R-HSA-3214858Reactome: R-HSA-427389Reactome: R-HSA-5617472Reactome: R-HSA-606279Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-8951664Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9679191Reactome: R-HSA-9710421Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Histone-Binding Protein Rbbp7 antibodyAnti-Histone Acetyltransferase Type B Subunit 2 antibodyAnti-Nucleosome-Remodeling Factor Subunit Rbap46 antibodyAnti-Retinoblastoma-Binding Protein 7 antibodyAnti-Rbbp-7 antibodyAnti-Retinoblastoma-Binding Protein P46 antibodyAnti-RBBP7 antibodyAnti-RBAP46 antibody |
Information sourced from Uniprot.org