Anti-RBBP4 antibody [R07-5D6] (STJA0034806)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human RbAp48
General Information
| Short Description | Rabbit monoclonal anti-RBBP4 for use in WB, IHC-F, IHC-P, ICC, IF and IP in Human, Mouse, Rat and Hamster samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-F/IHC-P/ICC/IF/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Hamster |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-5D6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | RBBP4 |
| Gene ID | 5928 |
| Uniprot ID | RBBP4_HUMAN |
| Immunogen | A synthetic peptide of human RbAp48 |
Additional Info
| Tissue Specificity | Expressed in neuroblastoma cells. |
| Function | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair. Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression. Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling. Component of the PRC2 complex, which promotes repression of homeotic genes during development. Component of the NURF (nucleosome remodeling factor) complex. |
| Protein Name | Histone-Binding Protein Rbbp4Chromatin Assembly Factor 1 Subunit CCaf-1 Subunit CChromatin Assembly Factor I P48 SubunitCaf-I 48 Kda SubunitCaf-I P48Nucleosome-Remodeling Factor Subunit Rbap48Retinoblastoma-Binding Protein 4Rbbp-4Retinoblastoma-Binding Protein P48 |
| Database Links | Reactome: R-HSA-1362277Reactome: R-HSA-1362300Reactome: R-HSA-1538133Reactome: R-HSA-156711Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214815Reactome: R-HSA-3214841Reactome: R-HSA-427389Reactome: R-HSA-5617472Reactome: R-HSA-606279Reactome: R-HSA-6804758Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69656Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9679191Reactome: R-HSA-9710421Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusChromosomeTelomereLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Antibody Names | Anti-Histone-Binding Protein Rbbp4 antibodyAnti-Chromatin Assembly Factor 1 Subunit C antibodyAnti-Caf-1 Subunit C antibodyAnti-Chromatin Assembly Factor I P48 Subunit antibodyAnti-Caf-I 48 Kda Subunit antibodyAnti-Caf-I P48 antibodyAnti-Nucleosome-Remodeling Factor Subunit Rbap48 antibodyAnti-Retinoblastoma-Binding Protein 4 antibodyAnti-Rbbp-4 antibodyAnti-Retinoblastoma-Binding Protein P48 antibodyAnti-RBBP4 antibodyAnti-RBAP48 antibody |
Information sourced from Uniprot.org