Anti-RASGRF2 antibody (STJA0009434)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human RASGRF2
General Information
| Short Description | Rabbit polyclonal anti-Ras-specific guanine nucleotide-releasing factor 2 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RASGRF2 |
| Gene ID | 5924 |
| Uniprot ID | RGRF2_HUMAN |
| Immunogen | Synthesized peptide derived from human RASGRF2 |
| Specificity | This antibody detects endogenous levels of RASGRF2 at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated by CDK5.down-regulates RASGRF2-mediated RAC1 activation. Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome. |
| Function | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. |
| Protein Name | Ras-Specific Guanine Nucleotide-Releasing Factor 2Ras-Grf2Ras Guanine Nucleotide Exchange Factor 2 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneTranslocates To Membranes When ActivatedFound Both At Cell Periphery And Along The Axon Of Neurons |
| Alternative Antibody Names | Anti-Ras-Specific Guanine Nucleotide-Releasing Factor 2 antibodyAnti-Ras-Grf2 antibodyAnti-Ras Guanine Nucleotide Exchange Factor 2 antibodyAnti-RASGRF2 antibodyAnti-GRF2 antibody |
Information sourced from Uniprot.org