| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ras-specific guanine nucleotide-releasing factor 2 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RASGRF2 |
| Gene ID: |
5924 |
| Uniprot ID: |
RGRF2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of RASGRF2 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human RASGRF2 |
| Post Translational Modifications | Phosphorylated by CDK5.down-regulates RASGRF2-mediated RAC1 activation. Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome. |
| Function | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. |
| Protein Name | Ras-Specific Guanine Nucleotide-Releasing Factor 2Ras-Grf2Ras Guanine Nucleotide Exchange Factor 2 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneTranslocates To Membranes When ActivatedFound Both At Cell Periphery And Along The Axon Of Neurons |
| Alternative Antibody Names | Anti-Ras-Specific Guanine Nucleotide-Releasing Factor 2 antibodyAnti-Ras-Grf2 antibodyAnti-Ras Guanine Nucleotide Exchange Factor 2 antibodyAnti-RASGRF2 antibodyAnti-GRF2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
