Anti-RAPH1 antibody (1-240) (STJ117701)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal RAPH1 (1-240) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAPH1 |
| Gene ID | 65059 |
| Uniprot ID | RAPH1_HUMAN |
| Immunogen Region | 1-240 |
| Immunogen Sequence | MEQLSDEEIDHGAEEDSDKE DQDLDKMFGAWLGELDKLTQ SLDSDKPMEPVKRSPLRQET NMANFSYRFSIYNLNEALNQ GETVDLDALMADLCSIEQEL SSIGSGNSKRQITETKATQK LPVSRHTLKHGTLKGLSSSS NRIAKPSHASYSLDDVTAQL EQASLSMDEAAQQSVLEDTK PLVTNQHRRTASAGTVSDAE VHSISNSSHSSITSAASSMD SLDIDKVTRPQELDLTHQG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human RAPH1 (NP_998754.1). |
Additional Info
| Tissue Specificity | Isoform RMO1-RAPH1 is ubiquitously expressed with highest levels in brain, heart, ovary and developing embryo. Isoform RMO1 is widely expressed with highest levels in liver. Low expression in B-cells. |
| Function | Mediator of localized membrane signals. Implicated in the regulation of lamellipodial dynamics. Negatively regulates cell adhesion. |
| Protein Name | Ras-Associated And Pleckstrin Homology Domains-Containing Protein 1Raph1Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 18 ProteinAmyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 9 ProteinLamellipodinProline-Rich Evh1 Ligand 2Prel-2Protein Rmo1 |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodiumFilopodiumCytoplasmCytoskeletonRecruited To The MembraneVia The Ph DomainBy The PhosphoinositidePi(34)P2Colocalizes With Enah/Vasp At The Tips Of Lamellipodia And FilopodiaAlso Colocalizes With The PathogensVaccinia And Enteropathogenic EColi (Epec) At The Interface Between The Pathogen And Their Actin |
| Alternative Antibody Names | Anti-Ras-Associated And Pleckstrin Homology Domains-Containing Protein 1 antibodyAnti-Raph1 antibodyAnti-Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 18 Protein antibodyAnti-Amyotrophic Lateral Sclerosis 2 Chromosomal Region Candidate Gene 9 Protein antibodyAnti-Lamellipodin antibodyAnti-Proline-Rich Evh1 Ligand 2 antibodyAnti-Prel-2 antibodyAnti-Protein Rmo1 antibodyAnti-RAPH1 antibodyAnti-ALS2CR18 antibodyAnti-ALS2CR9 antibodyAnti-KIAA1681 antibodyAnti-LPD antibodyAnti-PREL2 antibodyAnti-RMO1 antibody |
Information sourced from Uniprot.org