Anti-RAB21 antibody (60-140 aa) (STJ191274)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 60-140
General Information
| Short Description | Rabbit polyclonal anti-Ras-related protein Rab-21 (60-140 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB21 |
| Gene ID | 23011 |
| Uniprot ID | RAB21_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 60-140 |
| Immunogen Region | 60-140 aa |
| Specificity | RAB21 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB21 is involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10. |
| Protein Name | Ras-Related Protein Rab-21 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Endoplasmic Reticulum MembraneLipid-AnchorGolgi ApparatusTrans-Golgi NetworkGolgi Apparatus MembraneEarly Endosome MembraneCytoplasmic Vesicle MembraneCleavage FurrowCell ProjectionNeuron ProjectionColocalizes With Ankrd27 And Vamp7 In NeuritesIn Nonpolarized Epithelial Caco-2 CellsFound In The Endoplasmic ReticulumIn Polarized CellsObserved In Vesicles In The Apical CytoplasmDuring MitosisIn Mid-TelophaseLocalized In The Ingressing Cleavage FurrowIn Late TelophaseDetected At The Opposite Poles Of The Daughter CellsIn Vesicles At The Base Of Lamellipodia Formed By The Separating Daughter Cells |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-21 antibodyAnti-RAB21 antibodyAnti-KIAA0118 antibody |
Information sourced from Uniprot.org