• Western blot analysis of lysates from PC12 cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-RAB21 antibody (60-140 aa) (STJ191274)

SKU:
STJ191274

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ras-related protein Rab-21 (60-140 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RAB21
Gene ID: 23011
Uniprot ID: RAB21_HUMAN
Immunogen Region: 60-140 aa
Specificity: RAB21 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 60-140
Function Small GTPase involved in membrane trafficking control. During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis. Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general. As a result, may regulate cell adhesion and migration. Involved in neurite growth. Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10.
Protein Name Ras-Related Protein Rab-21
Database Links Reactome: R-HSA-8873719
Reactome: R-HSA-8876198
Cellular Localisation Endoplasmic Reticulum Membrane
Lipid-Anchor
Golgi Apparatus
Trans-Golgi Network
Golgi Apparatus Membrane
Early Endosome Membrane
Cytoplasmic Vesicle Membrane
Cleavage Furrow
Cell Projection
Neuron Projection
Colocalizes With Ankrd27 And Vamp7 In Neurites
In Nonpolarized Epithelial Caco-2 Cells
Found In The Endoplasmic Reticulum
In Polarized Cells
Observed In Vesicles In The Apical Cytoplasm
During Mitosis
In Mid-Telophase
Localized In The Ingressing Cleavage Furrow
In Late Telophase
Detected At The Opposite Poles Of The Daughter Cells
In Vesicles At The Base Of Lamellipodia Formed By The Separating Daughter Cells
Alternative Antibody Names Anti-Ras-Related Protein Rab-21 antibody
Anti-RAB21 antibody
Anti-KIAA0118 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance