Function | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. |
Protein Name | Rab11 Family-Interacting Protein 2Rab11-Fip2Nrip11 |
Database Links | Reactome: R-HSA-432040 |
Cellular Localisation | Cell ProjectionPhagocytic CupCell MembranePeripheral Membrane ProteinRecycling Endosome MembraneTranslocates With Rab11a From The Vesicles Of The Endocytic Recycling Compartment (Erc) To The Plasma Membrane |
Alternative Antibody Names | Anti-Rab11 Family-Interacting Protein 2 antibodyAnti-Rab11-Fip2 antibodyAnti-Nrip11 antibodyAnti-RAB11FIP2 antibodyAnti-KIAA0941 antibody |
Information sourced from Uniprot.org