Anti-RAB11FIP2 antibody (340-389 aa) (STJ95308)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RAB11FIP2 at the amino acid range 340-389
General Information
| Short Description | Rabbit polyclonal anti-Rab11 family-interacting protein 2 (340-389 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB11FIP2 |
| Gene ID | 22841 |
| Uniprot ID | RFIP2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RAB11FIP2 at the amino acid range 340-389 |
| Immunogen Region | 340-389 aa |
| Specificity | Rab11-FIP2 Polyclonal Antibody detects endogenous levels of Rab11-FIP2 protein. |
Additional Info
| Function | A Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity. Plays an essential role in phagocytosis through a mechanism involving TICAM2, RAC1 and CDC42 Rho GTPases for controlling actin-dynamics. |
| Protein Name | Rab11 Family-Interacting Protein 2Rab11-Fip2Nrip11 |
| Database Links | Reactome: R-HSA-432040 |
| Cellular Localisation | Cell ProjectionPhagocytic CupCell MembranePeripheral Membrane ProteinRecycling Endosome MembraneTranslocates With Rab11a From The Vesicles Of The Endocytic Recycling Compartment (Erc) To The Plasma Membrane |
| Alternative Antibody Names | Anti-Rab11 Family-Interacting Protein 2 antibodyAnti-Rab11-Fip2 antibodyAnti-Nrip11 antibodyAnti-RAB11FIP2 antibodyAnti-KIAA0941 antibody |
Information sourced from Uniprot.org